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Hodgkin’s Lymphoma Therapeutics Pipeline Analysis 2017 - Collaboration and Other Developments

The Hodgkin’s lymphoma therapeutics pipeline is expected to witness considerable growth in the coming years as the researchers are making novel drug delivery system for the treatment for cancer. The government agencies such as National Cancer Institute and American Cancer Society are supporting the growth of the Hodgkin’s lymphoma (HL) therapeutics pipeline by providing funding, designations and grants for speeding up the drug development process. High prevalence of cancer, increasing awareness regarding cancer treatment, technological advancements and high demand for safe and effective medication are driving the growth of the Hodgkin’s Lymphoma therapeutics pipeline.

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Hodgkin lymphoma (HL) or Hodgkin’s disease is an uncommon cancer of the lymphatic system, such as lymph nodes. The lymphatic system is made up of a network of vessels and glands that spread throughout the body. The vessels of lymphatic system known as lymphocytes carrying clear fluid known as lymph, contains lymphocytes (white blood cells that help combat infection). The lymphatic is a part of the human body’s immune system. In Hodgkin’s lymphoma, the patient experiences a painless swelling in a lymph node, usually in the neck, armpit or groin.

 

Ono Pharmaceuticals and Bristol-Myers Squibb are in the process of developing Opdivo for the treatment of Hodgkin’s disease. Seattle Genetics has developed ADCETRIS (brentuximab vedotin) as an antibody drug conjugate for Hodgkin’s disease. Merck & Co., Inc. has also developed Keytruda for the treatment of Hodgkin’s lymphoma. Though, major companies are developing promising drugs for Hodgkin’s lymphoma treatment, the new entrants are facing the challenge of fulfilling the relapsed or refractory (R/R) Hodgkin’s lymphoma patients’ unmet needs, and of bringing a reduction in the adverse effects of current treatments in the long term, thereby improving patients’ overall survival.

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Some of the companies having a pipeline of Hodgkin’s lymphoma therapeutics include Bristol-Myers Squibb Co., Merck & Co. Inc., Pfizer, Inc., F. Hoffmann-La Roche Ltd., Novartis AG, Affimed Therapeutics AG, Aeterna Zentaris Inc., Incyte Corporation, and 4SC AG.

Testicular Cancer Therapeutics Market Development, Growth and Demand Forecast to 2023

Global testicular cancer therapeutics market is growing with the increasing prevalence of testicular cancer. The market is expected to witness moderate growth, since there are already more than 15 drugs that exist in the market for the treatment of testicular cancer. Increasing prevalence of cancer and rising demand for the medications with better efficacy and less side effects can be attributed as an opportunity for oncology. The regulatory bodies such as USFDA, EMA are supporting the growth of the global market by providing increased funding, designations and grants for speeding up the drug development process.

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Testicular cancer is the tumor that develops in the testicles. Testicles are the glands found in men that produce testosterone hormone and sperms. The cause of testicular cancer is attributable to enormous growth of testicular cells due to some abnormalities, resulting in the formation of tumor in testicles, causing testicular cancer. Cryptorchidism, inguinal hernia, congenital abnormalities, abnormal testicular development and family history can increase the risk of testicular cancer. Mumps orchitis are also one of risk factors which is a very rare complication of mumps, which involves the inflammation of testicles. Pain, swelling, discomfort, sensation of heaviness and sudden fluid accumulation in scrotum are the main symptoms of testicular cancer.

Diagnosis of testicular cancer is done through a blood test, ultrasound and biopsy. Also, the type of testicular cancer is determined with the diagnosis along with its stage. There are two types of testicular cancer- seminoma testicular cancer and non- seminoma testicular cancer. After the diagnosis, the treatment options are selected according to the stage and the type of testicular cancer. The treatment options that are available to the patients are chemotherapy, radiation therapy and surgery. Surgery include orchidectomy, removal of both the testicles, lymph node surgery and hormone replacement therapy.

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Some of the key players operating in the global testicular cancer therapeutics market are Ovation Pharmaceuticals, Inc., ZIOPHARM Oncology Inc., Bristol-Myers Squibb Company, Hospira Inc., Teva Pharmaceutical Industries Ltd., Fresenius Kabi AG and Teva Parenteral Medicines, Inc.

Vascular Imaging Systems Market Size, Development and Demand Forecast to 2023

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According to the study, the global vascular imaging systems market is likely to grow significantly, during the forecast period, due to increasing healthcare expenditure, increasing prevalence of cancer and cardiovascular diseases and rising awareness about imaging techniques due to various conferences and seminars. In addition, growing geriatric population and launch of technologically advanced products contribute to the growth of the market. High cost, stringent regulatory requirements, shortage of helium for magnetic resonance imaging and increasing risk of cancer due to exposure to radiations are the key factors restraining the global market growth.

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Insights on market segments

As per the findings of research, based on product, the CT imaging system is the most preferred vascular imaging system, globally. Based on application, cardiology holds the maximum share of the global market. Hospitals have been the largest end users of the global vascular imaging systems market.

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North America stands as the largest vascular imaging systems market

Geographically, North America has been the largest market for vascular imaging systems, where the U.S. has been the largest contributor to the regional market. Increasing awareness about imaging techniques has been driving the growth of the North American market. In Europe, Germany has been the largest contributor to the market, followed by the U.K. and France. Asia-Pacific market is expected to grow at the highest CAGR, during 2017 - 2023, owing to increasing prevalence of cancer and cardiovascular diseases.

Key players in the vascular imaging systems market

Some of the key players in the global market include Siemens AG, General Electric Company, Hitachi Ltd., and Koninklijke Philips N.V., Carestream Health, Inc., Hologic, Inc., Esaote S.P.A, Shimazdu Corporation, Canon Inc., Orthoscan, Inc., and Fujifilm Corporation.

Breast Imaging Technologies Market Development, Growth and Forecast to 2020

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The global breast imaging technologies market is growing significantly due to technological advancement in the detection of breast cancer in the industry. Massive unexplored market in breast imaging technologies industry of developing economies are creating ample opportunities for the breast imaging technologies market to grow at a considerable rate in the coming years.

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The advanced research and development facilities and new product developments by the companies are supporting to address the demand for the breast imaging technologies industry. However, strict regulatory approval procedures, and unfavorable reimbursement policies in the developing countries are posing a challenge for the growth of the breast imaging technologies market.

Breast cancer is the most common cancer in women. According to International Agency for Research on Cancer (IARC) and World Health Organization (WHO), globally, approximately 1.7 million new cases of breast cancer were diagnosed in 2012. As the incidence of breast cancer is increasing significantly, development of improved technology with less radiation exposure is also expected to support the growth of the breast imaging technologies market.

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Geographically, North America will be leading the global breast imaging technologies market in the coming years due to technological advancement in breast imaging, rising awareness of early detection of breast cancer and increasing government initiatives and funding in research and product innovations in the region. Moreover, Asia-Pacific is the fastest growing region in the global breast imaging technologies market. The major reasons for the fastest growth in the region are increasing healthcare expenditure, increasing incidence and prevalence of breast cancer cases, increasing government initiatives and investment in breast imaging technologies, and improving healthcare infrastructure in the region. Moreover, the breast imaging technologies market is growing due to increasing awareness about women health in the emerging countries, such as India and China, of Asia-Pacific region.

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Some of the companies operating in the breast imaging technologies market are Toshiba Corporation, Aurora Imaging Technologies, Dilon Technologies, Inc., Gamma Medica, Inc., Sonocine, Inc., Siemens Healthcare, Philips Healthcare, GE Healthcare, Dune Medical Devices, U-Systems, Inc., and Hologic, Inc.

Estrogen Receptor-Positive Breast Cancer Pipeline Analysis, 2017

The study analyzed that the estrogen receptor positive breast cancer pipeline comprises approximately 74 drug candidates, of which nine products are in Phase III, 16 products in Phase II, 18 products in Phase I, and three products are in Pre-Clinical stage. The development of 14 ER+ breast cancer drug candidates was found to be inactive, and 14 products were discontinued. ER+ breast cancer is the most common type of breast cancer diagnosed and refers to the cancer cells that have receptors on their surface to bind with estrogen. Breast cancer is a syndrome that affects the breast tissues. In breast cancer, cells in the breast grow in an uncontrollable manner and form tumor, which can be felt as a lump or can be viewed under x-ray. Invasion of new therapeutic agents, such as gene therapy, cell therapy and monoclonal antibodies are expected to provide an effective and concrete treatment for the disease, more in the light of the new technologies available.

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Insights on pipeline analysis

As per the findings of the research, a major share of ER+ breast cancer pipeline drug candidates are being developed to be administered by oral route and rest by intravenous route and subcutaneous route. Most of the therapeutic candidates are being developed to be administered by oral route due to high patient compliance.

Several companies are developing ER+ breast cancer drug candidates in different phases. Novartis AG, Syndax Pharmaceuticals, Tesaro, Inc. and others have their ER+ breast cancer drug candidates in Phase III stage of development. Novartis AG has three drug candidates in Phase III stage and two drug candidates in Phase I clinical stage.

 

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Some of the key players developing drugs for Estrogen Receptor-Positive (ER+) breast cancer are Chipscreen Biosciences, Ltd., Eli Lilly & Company, Genentech, Inc., Novartis AG, Ipsen, Syndax Pharmaceuticals, Inc., Tesaro, Inc Astellas Pharma Inc., AstraZeneca plc, and Bayer AG.

Automotive Sunroof Market Trends, Size, Development and Forecast to 2022

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The global automotive sunroof market was valued at $4,924.5 million in 2015, and it is expected to grow at a CAGR of 10.9% during 2016 - 2022. The factors driving the growth of the global market includes growing need to control light inside vehicle, growing demand for premium cars, and greater glass surface area in automobiles, including larger sunroofs. Additionally, the development of technology for reducing cost and expanding functionality of sunroof glasses and increasing consumer preference towards automotive sunroof vehicles in developing nations are expected to further propel the global demand of automotive sunroof.

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Automotive sunroof refers to any roof opening in vehicle, such as one with a retractable metal panel. Modern sunroof consists of around 200 parts, and vehicle maker now use them and other roof system to help differentiate product offering to customers. Consumers now expect an increasingly high level of comfort in their cars, particularly where air conditioning and sun roof are concerned. Such equipment is no longer the exclusive domain of luxury cars. As the market is becoming increasingly competitive, vehicle makers are using sunroofs and other roof systems to help differentiate the product offering to customers. The demand for sunroof as an after sales market has also contributed to the growth of the global automotive sunroof market. The growing alternative fuel vehicle segments have forced the automotive innovators to develop sunroofs with built-in solar cells, which provide power to vehicles. The preference of car involving a sunroof is a major trend witnessed in the automotive sunroof market during the last few years.

Among the various vehicle types, the premium cars held the major market share in the global automotive sunroof market. The high-income group prefers premium cars owing to their aesthetic looks, convenient travel experience, and it also resembles the statues symbol in the society. Now-a-days sedan cars are extensively using sunroof systems, as the manufacturer are targeting middle income group people and also the convertible sunroofs are gaining popularity among the individuals. Thus, the sedan car segment is expected to witness the fastest growth in the global automotive sunroof market during the forecast period.

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Some of the major companies operating in the global automotive sunroof market include Webasto SE, Johnan America, Inc., Automotive Sunroof Company, Nippon Sheet Glass Co. Ltd., Yachiyo Industry Co., Ltd., Corning Inc., Meritor Inc., Aisin Seiki Co., Ltd., Inteva Products, LLC, and Inalfa Roof Systems Group B.V.

3D Bioprinting Market Size, Analysis, Growth and Demand Forecast to 2022

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The global 3D bioprinting market was valued at $98.6 million in 2015, and it is expected to grow at a CAGR of 35.9% during 2016 - 2022. The growth of the global market is largely driven by increasing large demand of tissues and organs for transplantation and the innovations and advancements in technology for 3D bioprinting. A large number of people across the globe are waiting for organ or tissue transplant, due to the huge gap in demand for organs transplant and donors. This has created huge traction in the 3D printing industry for developing live tissues and organs. Different companies along with academic institutes and laboratories are investing huge capital for 3D bioprinting research and development. Some of the other factors driving the growth of the global market include increasing research and development activities and increasing compliance for 3D bioprinting in drug discovery processes. Growing stem cell research and increasing adoption of 3D bioprinting in cosmetic industry are expected to create ample growth opportunities for the global market. However, the high cost of 3D bioprinting, lack of skilled professionals and stringent regulatory processes are the key barriers for the growth of the global market.

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Among the 3D bioprinting technologies, the pneumatic extrusion based 3D bioprinting would witness the fastest growth during the forecast period. Increasing adoption of pneumatic extrusion based 3D bioprinting in the industry and its high resolution are the major factors driving the growth of the pneumatic extrusion based 3D bioprinting market. Syringe based 3D bioprinting contributed the largest revenue in the global market in 2015. The technology along with pneumatic extrusion based technology accounted for over 60% share in the global market in 2015.

North America accounted for the largest share in the global market in 2015, owing to the technological advancements and innovations, and increasing research and development activities. The U.S. contributed largest revenue to the North American as well as global 3D bioprinting market. The country is expected to remain the largest market for 3D bioprinting globally during the forecast period. The huge capital investments along with the significant development in 3D bioprinting are the key driving factors of the U.S. 3D bioprinting market.

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Some of the players operating in the global market include Organovo Holdings, Inc., CELLINK, EnvisionTEC, BioBots, Cyfuse Biomedical K.K., Aspect Biosystems Ltd., 3D Bioprinting Solutions, Ourobotics, Advanced Solutions, Inc., GeSiM, Bio3D Technologies, 3Dynamic Systems Ltd., Nano3D Biosciences, Inc., Poietis, regenHU Ltd., and Aerotech Inc.