Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Inhibitors Pipeline Analysis and Demand Forecast to 2025
The global programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors market is valued at an estimated $4,926.4 million in 2016, and it is expected to grow at a CAGR of 23.4% during 2017 - 2025.
The growth of the global market is largely driven by the increased investment and funding, strong pipeline, and improved safety and efficacy. BGB-A317, a Phase I therapeutic candidate of BeiGene Ltd., gained $75 million funding to continued development of targeted oncology candidate. PD-1 and PD-L1 inhibitors are applicable to a wider range of tumor types such as advanced or metastatic non-small cell lung cancer, renal cancer, melanoma and others. These inhibitors lower the rate of severe toxicities and immune-mediated side-effects. These are also convenient to administer, and yield a good response rate of any single-agent immunotherapy. This creates huge traction in pharmaceutical industry to develop PD-1 and PD-L1 inhibitors for treatment of different types of cancer.
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PD-1 and PD-L1 inhibitors are highly growing immunotherapies that are being used in oncology therapy area. The pipeline of PD-1 and PD-L1 inhibitors is enriched with 47 drugs and there are approximately 245 active clinical studies. Currently, durvalumab from Astrazeneca and atezolizumab from Roche are among the most promising molecules in the pipeline, in terms of efficacy and safety. These molecules are in Phase III stage and expected to be launched in the coming years for the treatment of non-small cell lung cancer. There are many drugs in early stage of pipeline; thus, making PD1 and PDL1 inhibitors market very lucrative.
Among the different marketed PD-1 and PD-L1 inhibitor drugs, the largest revenue globally was generated from the sale of Opdivo in 2016. The global demand of Tecentriq is expected to witness high growth, primarily driven by the lack of approved competitor PD-L1 inhibitors drugs and high prevalence of urothelioma cancer.
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Some of the key players operating in the global market include Merck & Co., Inc., Bristol-Myers Squibb Company, AstraZeneca plc, Pfizer Inc., F. Hoffmann-La Roche AG, Novartis AG, Regeneron Pharmaceuticals, Inc., Ono Pharmaceutical Co., Ltd., and Merck KGaA.
Personal Protective Equipment Market Analysis, Size, Growth and Forecast to 2020
The stringent regulations related to occupational health and safety is the key growth driver for the global personal protective equipment market. The increasing consumer awareness about personal safety at workplace is another important factor for the growth of this market. The companies around the world are focusing on employee safety, due to up surge in workplace fatalities. The hand protection equipment dominates the product segment of the global personal protective equipment market; however protective clothing is expected to become the largest product segment by 2020. Based on industry type, manufacturing industry dominated the market in 2014.
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The personal protective equipment includes products related to the protection of eye, face, head, foot and legs, and hand and arms. The hazards of different types caused by falling of objects, colliding with sharp edges, interaction with chemicals, flying sparks and several others are caused at workplaces. Several codes of regulations (CFR) have been laid down by the Occupational Safety and Health Administration (OSHA), which states the employers’ liability to protect their employees from workplace hazards causing injuries. The major CFRs include eye and face protection, head protection, foot protection, electrical protective equipment, and hand protection. The non-compliance of such regulations and codes attract huge penalties to the employers. The prevalent regulations and certifications related to protection at workplace are issued by OSHA, American National Standards Institute (ANSI), and CSA Group.
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The U.S. is the major market for personal protective equipment globally. The major markets in Europe include Germany, the U.K., France, and Russia. The key markets in Asia-Pacific include China, India, and Japan. The increasing industrialization in Asia-Pacific, owing to high population growth is expected to significantly boost the growth of the market for personal protective equipment in the region. The emerging countries, such as Vietnam, Indonesia, and Brazil are expected to provide growth opportunity for the global personal protective equipment market.
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The global personal protective equipment market is fragmented with presence of large number of regional players. The major competitors in the global personal protective equipment market include 3M Company, Honeywell, Alpha Pro Tech Limited, Ansell Ltd., Avon Rubber PLC, JAL Group Italia SRL, COFRA SRL, Uvex Safety Group, Rock Fall Limited.
Farm Equipment Market Analysis, Size, Growth and Demand Forecast to 2020
The increasing population has been propelling the demand for food items, which is consequently driving the growth of the global farm equipment market. The up gradation in the technology, increasing government subsidies on agricultural machineries, growth of precision farming and easily available credit schemes from financial institutions are encouraging the growth of the global market. Asia-Pacific accounted for the largest share in the global market in 2014, owing to its large population that translates into demand for crops. Among the various types, the tractors segment dominated the global farm equipment market in 2014.
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Farm equipment includes machineries used for the production and maintenance of crops and agricultural livestock. Tractors are one of the essential farm equipment that serves several purposes in agriculture, including plowing, harrowing, and transportation of agricultural products. The harvesting equipment includes combine harvesters and threshers. The modern tractors are equipped with global positioning systems (GPS) and on-board computers. The expansion of precision farming has been positively impacting the growth of the farm equipment market. The farmers are up grading their traditional farm equipment with more advanced alternatives. The advent of do-it-yourself (DIY) repair tractors have also reduced the cost and hassle of tractor repairing, thus providing more comfort to farmers.
The government in different countries has been extending several subsidy programs to encourage farmers in their agricultural ventures. In 2004, China implemented subsidy policy for agricultural machineries, which increased over the years and now includes 12 agricultural categories. Around 175 types of agricultural machineries were subsidized by the Chinese government in 2015. During 2004 – 2012, the Chinese government dedicated $12 as subsidy for agricultural machineries. In order to promote food security in the country, the Chinese government has announced a subsidy scheme in 2015 for farm equipment, under which about 30% of the sales price of such equipment will be subsidized. The staple crop growers in the country, including sugar and cotton farmers will be prioritized.
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The major farm equipment markets in Europe include Germany, France, Italy, the U.K., Russia, Turkey, and Poland. Whereas the key markets in Asia-Pacific include China, India, Japan, and Australia. The major companies in the global market include Alamo Group Inc., AGCO Corporation, Deere & Company, Daedong industrial Company Limited, Escorts Group, and Netafim.
Hi-Fi System Market Analysis, Size, Development and Forecast to 2022
The global High-Fidelity (Hi-Fi) system market has experienced a considerable growth due to increasing demand of high quality music among audiophiles. Wireless devices have made its way across various audio products, such as speakers & sound bars, headphones, network media players, and others. The growing demand for wireless audio devices is expected to drive the growth of the global Hi Fi system market.
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High-fidelity equipment offers minimal noise and distortion and an accurate frequency response. The demand for wireless audio devices arises not only from the home applications, but also from the commercial and other niche applications such as security, military and automotive. Now-a-days, the Hi-Fi market is gaining maximum traction due to its increasing application in automotive sector. The emerging trends witnessed in the Hi-Fi market are increasing demand of wireless Hi-Fi speaker systems in cars, growing demand for home-theatre-in-a-box (HTIB), increasing number of consumers adopting technologies such as smart homes, overall growth in the car segment, and demand for luxury automotive in the developing economies.
The technological advancement in wireless audio devices such as wireless headphones and growing demand for portable devices such as tablets and smartphones are the major growth contributing factors for the global Hi-Fi system market. The increasing need of better sound quality and infotainment services creates an opportunity for the Hi-Fi system market. The size, design and connectivity of Hi-Fi products, such as bluetooth speakers, makes them most popular product among other audio products.
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Some of the major players operating in the global Hi-Fi system market include Bowers & Wilkins Group Ltd, Onkyo Corporation, Bose Corporation, Panasonic Corporation, Yamaha Corporation, DEI Holdings Inc., LG Electronics Co., Ltd., Sony Corporation, Harman International, Inc., Koninklijke Philips N.V., and Samsung Electronics Co. Ltd.
Care Management Solutions Market Size, Development, Growth and Forecast to 2022
The growth of global care management solutions market is led by growing geriatric population, increasing demand for quality of care and increasing government initiatives to promote patient-centric care, increasing prevalence of chronic diseases, advancing IT and big data capabilities and growing medical tourism. Initiatives to move the burden of threat from healthcare payers to providers and need to reduce healthcare cost are further expected to boost the demand of these solutions. The fastest increase in demand of care management solutions during the forecast period is expected to be witnessed in chronic care management segment, due to increasing demand of improving quality of care and save time for providers. Based on component, software segment leads the global market in terms of size, due to technological advancement in IT solution, growth of cloud computing and increased access of internet across the globe.
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Increasing prevalence of chronic diseases is driving the growth of the global care management solutions market due to increasing demand for quality of care. The prevalence of chronic diseases, such as heart disease, cancer, stroke and respiratory disease, are increasing due to the alteration in lifestyle and lack of access to preventive care. According to the Centers for Disease Control and Prevention (CDC), approximately 117 million people in the U.S. had one or more chronic health conditions in 2012.
The technological advancement in healthcare IT solutions, increasing adoption of cloud based model and increasing consumer awareness and participation in the healthcare delivery process is expected to create opportunities for the players in the market. In addition, immense unexplored market in developing economies are creating abundant opportunities for the care management solutions market to grow at a significant rate in the coming years. However, inadequate patient engagement, high cost of deployment, high investments required for supporting infrastructure, data security concerns, low usage of internet, and reluctance of provider to adopt care management solution are the key factors hampering the growth of the global market. In addition, lack of skilled professionals and lack of interoperability are also hindering the growth of the global care management solution market to an extent.
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The key players operating in the global market are Allscripts Healthcare solutions Inc., Cerner Corporation, Epic Corporation, Inc., Wellentive Inc., I2I System Inc, and IBM Corporation.
Automotive Fuel Tank Market Analysis, Size, Growth and Forecast to 2022
In the past decade, steel fuel tanks were majorly used by automotive producers, whereas in the current scenario, plastic fuel tanks are being mostly used.. The key reasons for the drop in demand for steel fuel tanks are safety, weight, permeability, packaging and cost associated with it. Around 95% of the total fuel tanks in Europe, 85% in U.S. and 40% in Asia are made of plastic. The main reasons behind the increased use of plastic fuel tanks are its light weight, resistance to corrosion, and ease of molding into unusual shapes.
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The automotive fuel tank market is driven by increasing trend of vehicle weight reduction, growing global vehicle production, and norms pertaining to evaporative emission. The increasing demand for vehicles, coupled with capacity expansion by OEMs in emerging economies has driven the global production of vehicles. The production volume for passenger car and light commercial vehicles (LCV) in Asia-Pacific accounted for more than 50% of the global production. The increasing production in the region is complimented by intensifying demand for passenger cars and LCV in the region. The improving economy and standard of living in countries such as China and India have resulted in increased sales volume of automotive. The high automotive production volume in Asia-Pacific has made it an attractive fuel tank market.
North America is expected to be the second largest automotive fuel tank market during the forecast period, owing to its increasing customer base and norms pertaining to evaporative emission in the region. This has resulted in increased manufacturing activities by local automotive OEMs in the region, and supporting the growth of the automotive fuel tank market. In Europe, Germany, France, U.K., Russia and Spain were the major automotive fuel tank markets in 2015.
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Some of the major competitors in the global automotive fuel tank market include Benteler AG, TI Automotive Inc., Yachiyo Industry Co. Ltd., Magna International Inc., Kautex Textron Gmbh & Co. KG., FTS Co., Ltd., The Plastic Omnium Group, Martinrea International Inc., Unipres Corporation, YAPP Automotive Parts Co., Ltd., and SMA Serbatoi S.P.A.
Automotive Diagnostic Scan Tools Market Trends, Analysis, Growth and Forecast to 2022
The global automotive diagnostic scan tools market has been growing steadily during the past few years. The major factors driving the automotive diagnostic scan tools market are stringent emission norms, increasing number of automotive workshops and increase in usage of electronics in automotive sector. The increasing number of aftermarket repair shops and growing vehicle electronics complexity are increasing the demand of these tools. Factors such as wireless scanning tools and software repair and diagnostic data are the opportunity for the automotive diagnostic scan tools market. The major factor restraining the automotive diagnostic scan tools market is the increase in raw material cost.
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Automotive diagnostic scan tools are arrangement of electronic software and devices that are used as diagnostic system interface in the vehicles. Their usage in the automotive sector is increasing because of the changing consumer’s inclination towards automated diagnostic system from manual system. These are used for the purpose of analyzing and detecting any malfunction in electronic systems in vehicles. These tools also help in upgrading and reprogramming the control modules in automobile. Today’s diagnostic scan tools are very efficient and refined, which are able to analyze very complex codes while executing diagnosis in the vehicle’s body, chassis and powertrain. They are used in auto workshops and service stations for every type of automobile.
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North America was globally the second largest market for automotive diagnostic scan tools in 2015 owing to the growing number of vehicle fleet in the region and increase in the number of auto service stations and workshops. The automotive diagnostic scan tools market is projected to witness the highest growth in Asia-Pacific during forecast period. The shift of automotive industry towards Asia-Pacific is expected to persist in the long run, as the purchasing power and requirement to own personal vehicle is strong in the region.
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Some of the major competitors in the global automotive diagnostic scan tools market include Delphi Automotive PLC, Softing AG, Noregon Systems Inc., AVL List GmbH, General Technologies Corp., Robert Bosch GmbH, ACTIA Group, Vector Informatik GmbH, Denso Corp., and DG Technologies.
